Study on the complexation between DNA and cationic porphyrin derivatives.
نویسندگان
چکیده
A water-soluble cationic porphyrin, 5,10,15,20-Tetra(N-methylpyridinium-4-yl)-21H,23H-porphyrin has been shown to intercalate selectively into the A3-G4 gap of C-quadruplexed DNA d(TTAGGG)4.
منابع مشابه
Spectroscopic study on the interaction of three water-soluble porphyrins with calf thymus DNA
Porophyrins and their metal derivatives are strong DNA binders with association constant of to . Some of these compounds have been used for the radiations sensitization therapy of cancer and are targeted to interact with cellular DNA. Binding of porphyrins to DNA changes the expectral and other physic chemical characteristic of porphyrins, The mode of binding can be extracted from inspection ...
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Derivatives of amino acids bearing a porphyrin moiety on a side chain were synthesized by coupling a porphyrin to a glutamic acid side chain; the utility of these compounds was demonstrated by their use in solid-phase synthesis of a peptide bearing a cationic porphyrin and by studying its DNA-binding properties.
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ورودعنوان ژورنال:
- Nucleic acids symposium series
دوره 48 شماره
صفحات -
تاریخ انتشار 2004